Metabolic Longevity

Dietary geroprotective peptides modulate Nrf2, IIS, and mTOR through three converging structural rules: molecular weight below 1 kDa for intestinal permeation, hydrophobic or aromatic C-terminal residues for Keap1 displacement and receptor docking, and ETGE-like sequence motifs that mimic endogenous signaling ligands. These features are now mappable by AI-driven structure-activity pipelines, directly linking food-protein sequence to conserved longevity network outputs.